GHK-Cu – Premium Research Peptide
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide first isolated from plasma samples in 1973. The peptide consists of three amino acids (Gly-His-Lys) complexed with copper(II) ions through high-affinity chelation. This coordination stabilizes copper in a redox-controlled form suitable for experimental systems. Endogenous GHK-Cu concentrations have been shown to vary across biological samples, making it a compound of significant interest in gene expression and metalloprotein research.
This product is intended for laboratory and research purposes only. Research Use Only.
Research Applications
GHK-Cu has been extensively studied in peer-reviewed literature for its role in multiple biological processes. The peptide provides researchers with a tool for investigating:
- Copper homeostasis and metalloprotein regulation
- Extracellular matrix synthesis and remodeling
- Matrix protein and glycosaminoglycan expression in fibroblast models
- Gene expression modulation (studies indicate GHK-Cu may influence over 4,000 genes at the transcriptional level)
- Antioxidant enzyme regulation and redox signaling
- Cellular stress response and matrix turnover mechanisms
Published research demonstrates that GHK-Cu interacts with extracellular matrix components, transcriptional regulators, and membrane-associated proteins. Studies suggest the peptide may stimulate both the synthesis and regulated breakdown of structural matrix proteins, including metalloproteinases and their inhibitors.
Technical Specifications
- Sequence: Gly-His-Lys·Cu2+
- CAS Number: 89030-95-5
- Molecular Formula:C14H23CuN6O4
- Molecular Weight: 403.92 g/mol
- PubChem CID: 73587
- Purity: ?99%
- Form: Lyophilized powder
- Storage: Store at -20°C, protected from light



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