GLP-3 RT

GLP-3 RT  – Premium Research Peptide

GLP-3 RT (LY3437943), is a synthetic research peptide consisting of 39 amino acids. This novel compound functions as a triple receptor agonist, simultaneously targeting glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors. The peptide’s unique molecular structure adopts a single continuous helical conformation, enabling multi-receptor engagement for advanced research applications.

This product is intended for laboratory and research purposes only. Research Use Only.

Research Applications

GLP-3 RT has emerged as a significant compound in metabolic research due to its ability to engage three distinct receptor systems simultaneously. Published preclinical and clinical research suggests the peptide may influence multiple metabolic pathways, making it a valuable tool for investigators studying:

• Receptor-signaling interactions across GLP-1, GIP, and glucagon pathways
• Comparative receptor activity and binding affinity studies
• Structure-activity relationships in multi-agonist peptides
• Metabolic pathway coordination and crosstalk mechanisms

Experimental data indicate GLP-3 RT exhibits differential receptor potency, with an EC50 of 0.0643 nM at the GIP receptor, 0.775 nM at the GLP-1 receptor, and 5.79 nM at the glucagon receptor. The peptide demonstrates dose-dependent pharmacological activity with a half-life of approximately six days in research models.

Studies published in peer-reviewed journals, including the New England Journal of Medicine and Cell Metabolism, have examined GLP-3 RT’s molecular mechanisms and receptor activation profiles, providing researchers with a well-characterized compound for metabolic investigations.

Technical Specifications

• CAS Number: 2381089-83-2
• Molecular Formula:C₂₀₅H₃₂₀N₅₆O₆₃S
• Molecular Weight: 4,703.47 g/mol
• Purity: ?99%
• Form: Lyophilized powder
• Storage: Store at -20°C, protected from light

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Disclaimer: This product is sold for research, laboratory, and analytical purposes only. Intended exclusively for qualified professionals in controlled research environments. Research Use Only.